Animal Tissue
Introduction
- Tissue: A group of cells with similar embryonic origin, structure, and function.
- Histology: The study of the structure and arrangement of tissues.
- Organization: Cells → Tissues → Organs → Organ Systems → Body.
- Cell Types:
- Somatic Cells: Body cells excluding sperm and ova (from Greek “soma” meaning body).
- Germ Cells: Sperm and ova, part of the reproductive system.
- Animal Tissues: Classified into four types:
- Epithelial Tissue
- Connective Tissue
- Muscular Tissue
- Nervous Tissue
10.2 Epithelial Tissue
- Definition: Forms covering on inner and outer surfaces of the body and organs.
- Characteristics:
- Cells are compactly arranged with little intercellular matrix.
- Rest on a non-cellular basement membrane.
- Cells are polygonal, cuboidal, or columnar with a single nucleus (central or basal).
- Avascular (no blood vessels), but has good regeneration capacity.
- Functions: Protection, absorption, transport, filtration, secretion.
- Classification:
- Simple Epithelium: Single layer of cells.
- Compound Epithelium: Two or more layers of cells, lowermost layer on basement membrane.
A. Simple Epithelium
- Squamous Epithelium:
- Structure: Flat, thin, polygonal cells with serrated margins, fitting like tiles (pavement epithelium). Central spherical/oval nucleus.
- Functions: Protection, absorption, transport, filtration, secretion.
- Locations: Blood vessels, alveoli, coelom.
- Cuboidal Epithelium:
- Structure: Cuboidal cells with a central spherical nucleus.
- Functions: Absorption, secretion.
- Locations: Lining of pancreatic duct, salivary duct, proximal/distal convoluted tubules of nephron.
- Columnar Epithelium:
- Structure: Tall, pillar-like cells; narrow inner ends, broad flat free ends with microvilli. Oval nucleus in lower half.
- Functions: Secretion, absorption.
- Locations: Inner lining of intestine, gall bladder, gastric glands, intestinal glands.
- Ciliated Epithelium:
- Structure: Cuboidal or columnar cells with hair-like cilia on free ends, oval nucleus at basal end.
- Functions: Moves materials in a specific direction, prevents entry of foreign particles.
- Locations: Buccal cavity (frog), nasal cavity, trachea, oviduct.
- Glandular Epithelium:
- Structure: Columnar, cuboidal, or pyramidal cells with large basal nucleus and secretory granules.
- Types:
- Unicellular: E.g., goblet cells in intestine.
- Multicellular: E.g., salivary gland.
- Classification by Secretion:
- Exocrine Glands: Have ducts, secrete at specific sites (e.g., salivary, sweat glands).
- Endocrine Glands: Ductless, release secretions into bloodstream (e.g., thyroid, pituitary).
- Functions: Secretes mucus, enzymes, hormones; lubricates respiratory/digestive tracts.
- Sensory Epithelium:
- Structure: Modified columnar cells with elongated neurosensory cells and sensory hairs.
- Function: Perceives external/internal stimuli.
- Locations: Nose (olfactory), ear (auditory hair cells), eye (photoreceptors).
- Germinal Epithelium:
- Structure: Cells divide meiotically to produce haploid gametes.
- Locations: Lining of seminiferous tubules, inner lining of ovary.
B. Compound Epithelium
- Stratified Epithelium:
- Structure: Nucleus in stratum germinativum; cells at free surface flatten (stratum corneum, lack nucleus).
- Function: Protection.
- Locations: Epidermis of skin, esophagus, cornea, vagina, rectum.
- Transitional Epithelium:
- Structure: Similar to stratified epithelium; cells change shape based on organ stretch.
- Function: Distension of organ.
- Location: Urinary bladder.
Cell Junctions
- Definition: Junctional complexes connecting epithelial cells laterally and to the basement membrane.
- Types:
- Tight Junctions (TJs): Maintain cell polarity, prevent lateral diffusion of proteins/ions.
- Gap Junctions (GJs): Allow passage of ions, small molecules, and chemical messages.
- Hemidesmosomes (HDs): Anchor cells to basement membrane via integrins, maintain tissue homeostasis.
- Desmosomes (Ds): Provide mechanical strength to epithelial tissue, cardiac muscles, meninges.
- Adherens Junctions (AJs): Involved in signaling and transcriptional regulation.
10.3 Connective Tissue
- Definition: Most widely spread tissue; binds, supports, and strengthens other tissues/organs.
- Characteristics:
- Contains variety of cells and fibres in abundant intercellular matrix.
- Highly vascular (except cartilage).
- Protects vital organs, acts as packing material, aids healing.
- Classification:
- Connective Tissue Proper: Loose and dense.
- Supporting Connective Tissue: Cartilage and bone.
- Fluid Connective Tissue: Blood and lymph.
A. Connective Tissue Proper
- Loose Connective Tissue:
- Matrix: Semisolid, jelly-like, gelatinous.
- Types:
- Areolar Tissue:
- Fibres: White (collagen, tensile strength), yellow (elastin, elastic).
- Cells:
- Fibroblasts: Large, flat, branching; produce fibres and matrix.
- Mast Cells: Oval, secrete heparin/histamine.
- Macrophages: Amoeboid, phagocytic.
- Adipocytes: Fat cells with eccentric nucleus.
- Functions: Packing material, connects organs/tissues, aids healing.
- Locations: Under skin, between muscles, bones, around organs, blood vessels, peritoneum.
- Adipose Tissue:
- Structure: Many adipocytes (round/polygonal, peripheral nucleus due to fat droplets), less matrix, few fibres/vessels.
- Types:
- White Adipose: Opaque, common in adults.
- Brown Adipose: Reddish-brown, many blood vessels.
- Functions: Insulation, shock absorber, energy storage.
- Locations: Sole, palm, around kidneys.
- Areolar Tissue:
- Dense Connective Tissue:
- Structure: Fibres and fibroblasts compactly arranged.
- Types:
- Dense Regular: Parallel collagen fibres.
- Tendons: Connect muscles to bones, contain white fibres (e.g., Achilles tendon).
- Ligaments: Connect bones at joints, elastic due to yellow fibres.
- Dense Irregular: Fibres/fibroblasts not orderly, found in dermis of skin.
- Dense Regular: Parallel collagen fibres.
B. Supporting Connective Tissue
- Cartilage:
- Characteristics: Pliable, tough; forms endoskeleton in cartilaginous fishes (e.g., shark).
- Structure: Matrix (chondrin) enclosed by perichondrium (collagenous fibres). Chondroblasts (immature cells) mature into chondrocytes in lacunae (2-8 per lacuna).
- Types:
- Hyaline Cartilage: Perichondrium present, bluish-white gel-like matrix, fine collagen fibres, elastic, compressible. Found in ends of long bones, epiglottis, trachea, ribs, larynx, hyoid.
- Elastic Cartilage: Perichondrium present, matrix with elastic fibres, few chondrocytes. Found in ear lobe, nose tip.
- Fibrocartilage: No perichondrium, matrix with collagen bundles, few chondrocytes. Most rigid, found in intervertebral discs, pubic symphysis.
- Calcified Cartilage: Rigid due to salt deposition, reduces joint flexibility in old age (e.g., head of long bones).
- Functions: Shock absorption, flexibility, reduces friction.
- Bone:
- Characteristics: Hard matrix (ossein) with hydroxyapatite (Ca₁₀(PO₄)₆(OH)₂).
- Structure:
- Enclosed by periosteum (tough membrane); blood vessels/nerves pierce it.
- Matrix in concentric lamellae with fluid-filled lacunae connected by canaliculi.
- Cells: Osteoblasts (active), osteocytes (inactive), osteoclasts.
- Haversian System: In compact bones, central canal with artery/vein/nerves.
- Types:
- Spongy Bone: No haversian system, reticular matrix with trabeculae, contains red bone marrow.
- Compact Bone: Haversian system, no spaces between lamellae.
- Functions: Support, protection, movement.
C. Fluid Connective Tissue
- Blood and Lymph: Vascular tissues, detailed in Class 12 (Circulation).
10.4 Muscular Tissue
- Definition: Contractile tissue with elongated cells (muscle fibres) covered by sarcolemma.
- Characteristics:
- Cytoplasm (sarcoplasm) contains myofibrils (actin, myosin proteins).
- Fibres contract on stimulation, highly vascular, innervated, many mitochondria.
- Types:
- Skeletal Muscles:
- Structure: Attached to bones, fasciculi wrapped by epimysium, each fasciculus by perimysium, myofibres with sarcolemma/sarcoplasm.
- Myofibrils: Contain sarcomeres (functional units) with:
- A band: Dark, myosin + actin, H zone (light area) with M line.
- I band: Light, actin only.
- Z line: Separates adjacent sarcomeres.
- Characteristics: Striated, voluntary, quick/strong contractions, multinucleate (peripheral nuclei).
- Types:
- Red Muscles: High myoglobin, oxygen from myoglobin/haemoglobin.
- White Muscles: Low myoglobin.
- Functions: Voluntary movements.
- Smooth Muscles:
- Structure: Spindle-shaped, unbranched, single central nucleus, myofibrils with more actin, less myosin, no striations.
- Characteristics: Non-striated, involuntary, slow/sustained contractions, innervated by autonomous nervous system.
- Locations: Walls of visceral organs, blood vessels (longitudinal/circular arrangement).
- Functions: Involuntary movements (e.g., peristalsis).
- Cardiac Muscles:
- Structure: Combine striated/non-striated features, indistinct sarcolemma, uni-nucleate (appear multinucleate), branched, connected by intercalated discs.
- Characteristics: Striated, involuntary, quick stimulus transfer, some self-impulse generating (myogenic heart in mammals, neurogenic in some animals).
- Location: Myocardium of heart wall.
- Functions: Heart contractions.
- Skeletal Muscles:
10.5 Nervous Tissue
- Definition: Composed of neurons (nerve cells) and neuroglia (supporting cells).
- Characteristics:
- No intercellular matrix.
- Neuroglia regenerate/divide; neurons do not (lack centriole).
- Neurons are excitable (change membrane potential) and conductive经典案例
- Functions: Impulse generation/conduction for quick communication.
Structure of a Neuron
- Cyton (Cell Body):
- Contains neuroplasm (granular cytoplasm) with nucleus, mitochondria, Golgi apparatus, RER, Nissl’s granules (RNA).
- Processes:
- Dendrons: Short, branched, carry impulses to cyton via dendrites.
- Axon: Single, elongated, cylindrical, bounded by axolemma, contains axoplasm (mitochondria, neurofibrils).
- Myelin Sheath: Fatty layer by Schwann cells, interrupted at Nodes of Ranvier (saltatory conduction).
- Neurilemma: Outer covering of myelin sheath.
- Telodendron: Terminal axon branches.
- Functional Types:
- Afferent (Sensory) Neuron: Carries impulses from sense organs to CNS (dorsal root of spinal cord).
- Efferent (Motor) Neuron: Carries impulses from CNS to effector organs (ventral root of spinal cord).
- Interneuron: Processes/integrates sensory impulses, activates motor neurons.
- Structural Types:
- Unipolar Neuron: Single process (axon + dendron from one point), e.g., dorsal root ganglion.
- Bipolar Neuron: Two processes (dendron + axon from opposite poles), e.g., retina, olfactory epithelium.
- Multipolar Neuron: Star-shaped cyton, one axon, multiple dendrons, e.g., brain, spinal cord.
- Myelinated vs. Non-Myelinated Fibres:
- Myelinated: Fatty myelin sheath, white, fast saltatory conduction, e.g., cranial nerves.
- Non-Myelinated: No myelin, grey, slower conduction, e.g., autonomous nervous system nerves.
- Synapse: Functional contact between axonal ends and dendrites (detailed in Class 12).
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